Figure 12.

Illustrative stomach (a–c), small intestine (d–f), and colon (g,h,i) congestion microscopic presentation (HE staining; magnification 100× (a–c), scale bar 200 μm; magnification 200× (d–i), scale bar 200 μm) in the sotalol control rats assessed following application of sotalol, given therapy application at 15 min (a,d,g) (period 0–15 min), and at 180 min (b,e,h) (period 0–180 min) or at 180 min (c,f,i) (period 90–180 min). Saline medication was given as an early application immediately after sotalol (a,b,d,e,g,h), or as delayed post-treatment (at 90 min and assessment at 180 min sotalol-time) (c,f,i). Marked dilatation of submucosal blood vessels and moderate dilatation of intramucosal blood vessels occurred in the stomach, and small and large intestine.