Table 1.
Relative volume (control/treated) (%) of the brain, heart, azygos vein, in rats at 15 min and 90 min, and 180 min following sotalol application. Therapy included BPC 157 (10 μg/kg or 10 ng/kg) or saline (5 mL/kg). They were given as an intragastric administration at 5 min following sotalol for assessment at 15 min (period 0–15 min sotalol-time), 90 min (period 0–90 min sotalol-time) and 180 min (period 0–180 min sotalol-time). As a delayed regimen (period 90–180 min sotalol-time), the therapy was given as an intragastric administration at 90 min sotalol-time for assessment at 180 min sotalol-time. Means ± SD, * p ˂ 0.05, at least, vs. control.
| Relative Volume (Control/Treated) (%) of the Brain, Heart, Azygos Vein, in Rats at 30 min and 90 min, and 180 min following Sotalol Application | ||||
|---|---|---|---|---|
| Periods Assessed in Relation to the Medication Application |
0–15 min | 0–90 min | 0–180 min | 90–180 min |
| Relative volume (control/treated) (%) of the brain, in vivo, Means ± SD |
||||
| BPC 157 10 μg/kg | 111 ± 3 * | 111 ± 3 * | 116 ± 3 * | 110 ± 3 * |
| BPC 157 10 ng/kg | 112 ± 3 * | 112 ± 3 * | 114 ± 3 * | 111 ± 3 * |
| Relative volume (control/treated) (%) of the heart, Means ± SD |
||||
| BPC 157 10 μg/kg | 135 ± 5 * | 139 ± 7 * | 146 ± 6 * | 139 ± 7 * |
| BPC 157 10 ng/kg | 132 ± 6 * | 142 ± 5 * | 144 ± 5 * | 141 ± 6 * |
| Relative volume (control/treated) (%) of the inferior caval vein, Means ± SD |
||||
| BPC 157 10 μg/kg | 155 ± 8 * | 149 ± 9 * | 156 ± 6 * | 199 ± 10 * |
| BPC 157 10 ng/kg | 151 ± 9 * | 155 ± 8 * | 159 ± 9 * | 191 ± 11 * |
| Relative volume (control/treated) (%) of the superior mesenteric vein, Means ± SD |
||||
| BPC 157 10 μg/kg | 225 ± 8 * | 229 ± 9 * | 216 ± 9 * | 289 ± 10 * |
| BPC 157 10 ng/kg | 222 ± 9 * | 227 ± 8 * | 224 ± 9 * | 281 ± 8 * |
| Relative volume (control/treated) (%) of the azygos vein, Means ± SD |
||||
| BPC 157 10 μg/kg | 35 ± 6 * | 69 ± 7 * | 66 ± 5 * | 68 ± 7 * |
| BPC 157 10 ng/kg | 32 ± 7 * | 67 ± 8 * | 62 ± 9 * | 61 ± 68 * |
| Relative volume (control/treated) (%) of the abdominal aorta, Means ± SD |
||||
| BPC 157 10 μg/kg | 32 ± 6 * | 66 ± 7 * | 76 ± 8 * | 43 ± 7 * |
| BPC 157 10 ng/kg | 35 ± 7 * | 63 ± 8 * | 72 ± 9 * | 41 ± 6 * |
| Relative volume (control/treated) (%) of the brain, ex vivo, Means ± SD |
||||
| BPC 157 10 μg/kg | 114 ± 3 * | 110 ± 2 * | 116 ± 3 * | 111 ± 3 * |
| BPC 157 10 ng/kg | 113 ± 3 * | 111 ± 3 * | 115 ± 3 * | 112 ± 3 * |