Skip to main content
. 2023 Jun 30;11(7):1183. doi: 10.3390/vaccines11071183

Figure 4.

Figure 4

Longitudinal analysis of anti-RBD IgA and IgG and anti-spike IgG serum production for the BNT162b2, ChAdOx1 nCoV-19, and CoronaVac vaccines. Serum from individuals immunized with ChAdOx1 nCoV-19 (A,D,G), BNT162b2 (B,E,H), and CoronaVac (C,F,I) was collected at times T1 (pre-vaccine: BNT162b2 n = 7; ChAdOx1 nCoV-19 n = 32), T2 (1 month after application of the second dose: BNT162b2 n = 26; ChAdOx1 nCoV-19 n = 31), T3 (4–6 months after application of the second dose or pre-third dose: BNT162b2 n = 21; ChAdOx1 nCoV-19 n = 30; CoronaVac n = 17), and T4 (1 month after application of the third dose: BNT162b2 n = 20; ChAdOx1 nCoV-19 n = 26; CoronaVac n = 10). Whole blood of individuals from the ChAdOx1 nCoV-19 and BNT162b2 groups was collected in the four different periods; however, for performing the paired analysis, the T1 collection of BNT162b2 was disregarded due to the reduced number of samples (n = 7). For members of the CoronaVac group, only times T3 and T4 were collected. Detection of anti-RBD IgA (A–C) and IgG (D–F) and anti-spike IgG (G–I) antibodies was performed via the enzyme immunoassay (ELISA) described in the methods section. The results are expressed through the index calculated between the ratio: mean optical density (OD) of the sample/cutoff (S/CO-Signal/Cutoff). Each point represents a single individual. The end of the bar indicates the median value and the horizontal bars above and below the median indicate the 95% confidence interval. The red dotted line indicates the median of each point. The Wilcoxon Matched-Pairs test was used to compare the indices of induced antibodies between collection times. Statistical significance was adopted for p < 0.05.