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. 2023 Jul 17;16(7):1013. doi: 10.3390/ph16071013

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Molecular docking simulations (A) MIF and arketamine interacting in the center of protein. (B) PDE3A and esketamine in the X5M binding site. (C) PDE3A and arketamine in the X5M binding site. (D) PDE7A and esketamine in the IBM binding site. (E) PDE7A and arketamine in the IBM binding site. (F) PDE5A and esketamine in the 5GP binding site. (G) PDE5A and arketamine in the 5GP binding site. (H) Structure of 6D6T, which is a GABA_Aα1β2γ2 receptor, showing the neurosteroid (in left) and benzodiazepine (in right) binding sites. (I) GABA_Aα1β2γ2 receptor and esketamine in the neurosteroid binding site. (J) GABA_Aα1β2γ2 receptor and esketamine in the benzodiazepine binding site.