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. 2023 Jun 28;12(7):883. doi: 10.3390/pathogens12070883

Figure 5.

Figure 5

Changes in the state of histone acetylation and lactylation. (A) (Above). Western blot of acetylated histones. (Below). Relative quantification of H2/H3 acetylated histones in HeLa control and exposed for 24 h to culture supernatants of L. crispatus (S L.c) or L. reuteri (S L.r). (B) (Above). Western blot of lactylated histones. (Below). Relative quantification of H4 lactylated histones in HeLa control and treated with culture supernatants of L. crispatus or L. reuteri for 24 h. Densitometry arbitrary units (A.U.) are normalized by H1 histone. Results are given as means ± SD of three independent experiments and are compared to controls, taken as 100%. (* p < 0.05; ** p < 0.001; *** p < 0.0001).