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. 2023 Jun 24;13(7):787. doi: 10.3390/metabo13070787

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Transmethylation pathway. S-Adenosylhomocysteine hydrolase (SAHH) catalyzes the reversible reaction which converts S-adenosylhomocysteine (SAH) to homocysteine and adenosine (Ado). Ado can be phosphorylated to AMP by adenosine kinase (ADK). Methionine synthase (MetS) converts homocysteine into methionine. Methionine adenosyl transferase (MetAT) catalyzes the formation of S-adenosylmethionine (SAM). SAM is the donor of the methyl group in the transmethylation reactions catalyzed by methyltransferases (MethylT). X: acceptor of the methyl group. SAH is an inhibitor of MethylT (dashed line). THF: tetrahydrofolate; PPi: inorganic pyrophosphate; Pi: inorganic phosphate.