Table 1.

In vitro activity of antileishmanial drugs against promastigotes and intracellular amastigotes of the L. (L.) infantum LD strain and the ME clinical isolate.

Drugs	Promastigotes c		Intracellular Amastigotes c		CC50 d
	LD	ME	LD	ME
AmB a	19.83 ± 4.39	26.34 ± 3.87	5.17 ± 0.95	8.84 ± 2.32	127.36 ± 0.94
SbV b	-	-	269.40 ± 7.23	314.93 ± 5.84	>2000
SbIII b	131.06 ± 2.60	163.10 ± 2.06	-	-	-
MF b	16.15 ± 1.36	13.28 ± 1.65	1.53 ± 0.45	1.46 ± 0.21	49.52 ± 2.93
PEN b	4.04 ± 1.12	2.47 ± 0.28	0.11 ± 0.01	0.10 ± 0.013	0.36 ± 0.02
PM b	78.71 ± 3.15	74.28 ± 4.45	1.71 ± 0.62	2.05 ± 0.60	536.60 ± 27.1

^a Concentrations in nM; ^b Concentrations in µM; ^c EC₅₀ mean values ± standard deviation; ^d Toxicity on BMDM. CC₅₀ values for AmB, MF, SbV, and PM were previously reported [22,26,27]. CC₅₀ for PEN was determined as described by Coser et al. [26]. (-) Data not determined.