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. 2023 Jun 23;15(7):1422. doi: 10.3390/v15071422

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© 2023 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Pellino proteins contain highly conserved functional domains. Human Pellino1, Pellino2, and Pellino3 were aligned with the Melanoplus sanguinipes entomopoxvirus (MsEPV) Pellino protein using Clustal Omega at https://www.ebi.ac.uk/Tools/msa/clustalo/ (accessed on 12 May 2023). Stars (*) and dots (: and .) above the alignment indicate, respectively, identical and similar amino acids in the human proteins. Stars (*) and dots (: and .) below the alignment indicate, respectively, identical and similar amino acids between the human proteins and MsEPV Pellino. The FHA domain is shown in green. The RING domain is shown in red.