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Pellino proteins promote recruitment of leukocytes into tissues. HSV-1 establishes lifelong latent infections in neurons. Upon reactivation, HSV-1 reemerges from axons innervating the skin (shown) or mucosa. Viral replication in epithelial keratinocytes promotes expression of several pro-inflammatory cytokines in a Pellino1-dependent manner. While IL-1 and IL-36 facilitate recruitment of neutrophils from the circulation, GPR15LG is chemotactic to T cells expressing GPR15.
