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Cell death pathways are modified by Pellino1. Pellino1 can suppress necroptosis through K48 ubiquitination of RIPK3. Pellino1-mediated induction of survival genes, such as cFLIP, and K63 ubiquitination of RIPK1 inhibit caspase-8 activation and thus, apoptosis. Through K63 ubiquitination, Pellino1 activates Beclin1 and autophagy. Red Xs indicate pathways that cannot take place.
