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. 2023 Jun 30;11(7):569. doi: 10.3390/toxics11070569

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Photomicrography of liver sections showing normal liver tissue in (A) control group and (B) the 50 mg/Kg nano-emulsion treatment group with normal central vein (cv), blood sinusoids (S), and nucleus (N). (C,D) Imidacloprid-treated groups at conc. of 14 and 28 mg/kg bw/day. (F,G) Chlorpyrifos-treated groups at conc. of 1 and 2 mg/kg bw/day, showing few inflammatory cell infiltrations (arrow), dilated sinusoids (S), and pyknotic nuclei (P). (E) Imidacloprid-treated group at conc. of 54 mg/kg bw/day. (H) Chlorpyrifos-treated group at conc. 4 of mg/kg bw/day showing moderate degeneration changes with increased inflammatory cell infiltration (arrow), dilated sinusoids (S), and pyknotic nuclei (P). (I) Imidacloprid group at conc. of 54 mg/kg bw/day plus 50 mg/kg bw/day nano-emulsion treatment. (J) Chlorpyrifos group at conc. of 4 mg/kg bw/day plus 50 mg/kg bw/day nano-emulsion showing almost normal structure with few dilated sinusoids (S) and pyknotic nuclei (P). (H&E X 200).

Photomicrography of liver sections showing normal liver tissue in (A) control group and (B) the 50 mg/Kg nano-emulsion treatment group with normal central vein (cv), blood sinusoids (S), and nucleus (N). (C,D) Imidacloprid-treated groups at conc. of 14 and 28 mg/kg bw/day. (F,G) Chlorpyrifos-treated groups at conc. of 1 and 2 mg/kg bw/day, showing few inflammatory cell infiltrations (arrow), dilated sinusoids (S), and pyknotic nuclei (P). (E) Imidacloprid-treated group at conc. of 54 mg/kg bw/day. (H) Chlorpyrifos-treated group at conc. 4 of mg/kg bw/day showing moderate degeneration changes with increased inflammatory cell infiltration (arrow), dilated sinusoids (S), and pyknotic nuclei (P). (I) Imidacloprid group at conc. of 54 mg/kg bw/day plus 50 mg/kg bw/day nano-emulsion treatment. (J) Chlorpyrifos group at conc. of 4 mg/kg bw/day plus 50 mg/kg bw/day nano-emulsion showing almost normal structure with few dilated sinusoids (S) and pyknotic nuclei (P). (H&E X 200).