mRNA |
messenger RNA |
LNP |
lipid nanoparticles |
PEG |
polyethylene glycol |
IV |
intravenous |
siRNA |
small interfering RNA |
DSPC |
1,2-distearoyl-sn-glycero-3-phosphocholine |
MPS |
mononuclear phagocyte system |
RISC |
RNA-induced silencing complex |
ApoE |
Apolipoprotein E |
LDL |
low-density lipoprotein |
LDL-R |
low-density lipoprotein receptors |
IM |
intramuscular |
IVT |
in vitro translation |
RSV |
respiratory syncytial virus |
F |
fusion protein |
FBS |
fetal bovine serum |
Pen/Strep |
penicillin-streptomycin |
°C |
degrees Celsius |
CO2
|
carbon dioxide |
rH |
relative humidity |
PBS |
phosphate-buffered saline |
BSA |
bovine serum albumin |
mAb |
monoclonal antibody |
4-PL |
4-parameter logistics |
DGC |
density gradient centrifugation |
N:P |
ratio of amine (N) groups of lipids to the phosphates (P) on mRNA |
MFI |
mean fluorescence intensity |
PEG-DMG |
1,2-dimyristoyl-sn-glycero-3-methoxypolyethylene glycol |
DLS |
dynamic light scattering |