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. 2023 Jul 22;16(7):1041. doi: 10.3390/ph16071041

Figure 8.

Figure 8

Healthy (1) and sick (2) rats. Necrotic area (arrow) in the wall of the large intestine. (3) Healthy rat, macroscopic view after sacrification. (4) Section of healthy duodenum: Goblet cells (a), Lamina propria (c), Crypt cells (b), Submucosa (d), healthy Brunner’s glands. (B), Duodenum, HE, bar = 45 μm. (5) Sick rat, thickening of the duodenum due to inflammatory infiltration (arrows). (6) villus distortion and villi epithelial shedding in their apical regions (a), loss in crypts (c), lamina inflammatory cell infiltrates extending into the propria (b) and submucosa (d), disrupted Brunner’s glands (B) Duodenum, HE, bar = 45 μm. (7) Loss of crypts (c) and goblet cells (b), lamina in the propria mononuclear cell infiltration (a), Brunner’s Glands (B). (8) thickened villi with loss of goblet cells in epithelial layer thinned areas in the epithelium (a thick arrow), lamina dense mononuclear cell infiltrates in the propria (b, thin arrow). Duodenum, HE, Bar = 20 μm. (9) Decreased inflammatory cell infiltrates in thick and coarsened villi (a), decreased submucosal edema. Brunner’s glands (B). (10) lamina inflammatory cells in the propria (a). Duodenum HE, Bar = 20 μm. (11) Villi, some of which are coarse and thick, sometimes fused with each other(a), lamina reduced mononuclear cell infiltration in the propria (b) and submucosa (c). Duodenum, HE, bar = 90 μm. (12) increased mitotic activity in crypts (arrows, (a)) alongside regenerative hyperchromatic epithelial cells (arrowheads, (b)). Duodenum HE, Bar = 20 μm.