Table 1.
Identified QTLs and candidate genes associated with high levels of IFNɣ.
| BTA 1 | QTL Start (bp) | QTL End (bp) | Peak p-Value of Peak SNP | Regression Coefficient (b) | Genes in QTL 2 | No. of SNPs in QTL |
|---|---|---|---|---|---|---|
| 1 | 26,283,242 | 26,283,242 | 3.34 × 10−7 | 0.526 | ROBO1 | 1 |
| 1 | 90,034,825 | 90,360,896 | 4.42 × 10−7 | 1.127 | 5S_rRNA, TBL1XR1, ENSBTAG00000054926 | 3 |
| 2 | 41,453,339 | 41,453,339 | 4.42 × 10−7 | 1.127 | 1 | |
| 2 | 90,850,109 | 90,850,109 | 1.51 × 10−7 | 0.474 | TBL1XR1, SNORD11B, SNORD11, BMPR2 | 1 |
| 2 | 111,599,011 | 111,599,011 | 3.76 × 10−8 | 0.843 | 1 | |
| 3 | 88,432,545 | 88,432,545 | 5.32 × 10−8 | 1.223 | 1 | |
| 4 | 31,901,616 | 31,901,616 | 5.32 × 10−8 | 1.223 | GPNMB, MALSU1, IGF2BP3, ENSBTAG00000054861 | 1 |
| 7 | 512,191 | 941,753 | 1.36 × 10−8 | 0.720 | 5S_rRNA, FLT4, CNOT6, GFPT2, MAPK9 | 5 |
| 9 | 9,107,205 | 9,107,205 | 5.32 × 10−8 | 1.223 | 1 | |
| 9 | 42,469,434 | 42,469,434 | 5.32 × 10−8 | 1.223 | SOBP | 1 |
| 10 | 27,643,294 | 27,643,294 | 1.13 × 10−8 | 0.854 | OR4G10, OR4F67B, OR4G18, OR4K36 | 1 |
| 10 | 37,469,311 | 37,833,767 | 3.07 × 10−9 | 0.811 | PLA2G4E, PLA2G4D, PLA2G4F, VPS39, TMEM87A, GANC, CAPN3, ZNF106, SNAP23, LRRC57, HAUS2 | 3 |
| 10 | 41,108,685 | 41,108,685 | 2.18 × 10−7 | 1.105 | 1 | |
| 10 | 54,450,209 | 54,461,425 | 2.27 × 10−9 | 1.338 | NEDD4, ENSBTAG00000031396 | 2 |
| 10 | 78,308,107 | 78,308,107 | 2.18 × 10−7 | 1.105 | 1 | |
| 10 | 79,501,139 | 79,957,849 | 3.55 × 10−10 | 0.839 | PLEKHH1, PIGH, ARG2, U6, VTI1B, RDH11, RDH12, ZFYVE26, RAD51B, ENSBTAG00000054736 | 9 |
| 11 | 7,148,731 | 7,148,731 | 6.81 × 10−9 | 1.036 | IL1RL1, IL18R1 | 1 |
| 11 | 26,763,300 | 26,794,996 | 8.58 × 10−10 | 1.058 | SLC3A1, PREPL, CAMKMT, ENSBTAG00000040564, ENSBTAG00000043226 | 2 |
| 12 | 78,134,904 | 78,134,904 | 3.16 × 10−7 | 0.536 | ITGBL1, 5S_rRNA, FGF14 | 1 |
| 12 | 78,813,208 | 78,813,208 | 4.52 × 10−7 | 0.338 | 1 | |
| 13 | 16,268,793 | 16,268,793 | 5.32 × 10−8 | 1.223 | ITIH5 | 1 |
| 15 | 65,654,411 | 65,654,411 | 9.20 × 10−8 | 1.138 | CD44 | 1 |
| 16 | 44,888,428 | 45,019,492 | 7.68 × 10−10 | 0.613 | RERE, bta-mir-2285ck, SLC45A1 | 2 |
| 16 | 46,077,301 | 47,047,708 | 2.77 × 10−8 | 0.619 | DNAJC11, THAP3, PHF13, KLHL21, ZBTB48, TAS1R1, NOL9, PLEKHG5, TNFRSF25, ESPN, HES2, ACOT7, GPR153, ENSBTAG00000054938, ENSBTAG00000049238 | 7 |
| 16 | 72,020,440 | 72,020,440 | 4.42 × 10−7 | 1.127 | RD3, TRAF5, RCOR3 | 1 |
| 16 | 74,098,459 | 74,098,459 | 4.52 × 10−7 | 0.598 | 1 | |
| 17 | 8,929,084 | 8,929,084 | 2.27 × 10−9 | 1.338 | 1 | |
| 17 | 57,930,217 | 58,393,881 | 3.13 × 10−8 | 0.338 | FBXO21, TESC, FBXW8, RNFT2, SPRING1, U6, ENSBTAG00000053074, ENSBTAG00000037415, ENSBTAG00000051326, ENSBTAG00000053055 | 3 |
| 20 | 37,487,725 | 37,487,725 | 2.18 × 10−7 | 1.105 | 1 | |
| 20 | 38,295,510 | 38,295,510 | 5.32 × 10−8 | 1.223 | CAPSL, IL7R | 1 |
| 21 | 13,584,472 | 13,584,472 | 2.27 × 10−9 | 1.338 | 1 | |
| 21 | 58,429,839 | 58,429,839 | 1.03 × 10−7 | 0.922 | PRIMA1 | 1 |
| 22 | 12,939,505 | 12,984,148 | 3.85 × 10−7 | 0.502 | MYRIP, ENSBTAG00000049890 | 2 |
| 22 | 28,603,524 | 28,603,524 | 2.00 × 10−7 | 0.615 | 1 | |
| 22 | 33,464,942 | 33,464,942 | 5.60 × 10−8 | 0.553 | TAFA1 | 1 |
| 25 | 12,368,203 | 12,394,807 | 5.32 × 10−8 | 1.223 | 3 | |
| 26 | 8,076,021 | 8,076,021 | 1.36 × 10−7 | 0.511 | PRKG1 | 1 |
| 26 | 12,482,172 | 12,499,709 | 2.18 × 10−7 | 1.105 | HTR7, RPP30, ANKRD1 | 2 |
| 26 | 15,176,321 | 15,176,321 | 8.37 × 10−11 | 0.994 | 5S_rRNA, ASMTL, SLC25A6, ENSBTAG00000051075, ENSBTAG00000052863, ENSBTAG00000052720, ENSBTAG00000055018 | 1 |
| 28 | 38,626,680 | 38,626,680 | 2.57 × 10−7 | 0.675 | 1 |
1 Chromosome QTL location. 2 Candidate genes within the identified QTL.