Table 3.

Summary of current guidelines on PPI use for NV-UGB.

	American College of Gastroenterology (ACG) (2021) [11]	International Consensus Group (2019) [10]	Asia-Pacific Working Group (2018) [25]	European Society of Gastrointestinal Endoscopy (ESGE) (2021) [32]
Post-endoscopy finding high-risk lesion	IV bolus + infusion	IV bolus + infusion	High-dose PO PPI as adjunct	IV bolus + infusion
	High-dose intermittent, IV or PO	Neither for nor against intermittent IV	No comment on intermittent IV	Can consider intermittent IV or high-dose PO
Pre-endoscopy	No recommendation. Previously recommended considering IV bolus + infusion	No comment Previously recommended IV bolus + infusion in 2010 version of guidelines	No agreement on recommending PPI	Consider IV bolus + infusion