Table 1.
Engineered viruses
| Virus name | gDa | gH | gI | gE | UL24 |
|---|---|---|---|---|---|
| KNGF | Y38 | WT | WT | WT | WT |
| KNGFΔ38 | Δ38 | WT | WT | WT | WT |
| KNGF-Eʹ | Y38 | WT | WT | V154M | WT |
| KNGF-Iʹ | Y38 | WT | I286F | WT | WT |
| KNGF-EʹIʹ | Y38 | WT | I286F | V154M | WT |
| KNGF-Hʹ | Y38 | A732V | WT | WT | WT |
| KNGF-HʹEʹ | Y38 | A732V | WT | V154M | WT |
| KNGF-HʹIʹ | Y38 | A732V | I286F | WT | WT |
| KNGF-HʹIʹEʹ | Y38 | A732V | I286F | V154M | WT |
| KNGF-24ʹ | Y38 | WT | WT | WT | C103Y |
| KNGF-EʹIʹ24ʹ | Y38 | WT | I286F | V154M | C103Y |
| KNGF-Hʹ24ʹ | Y38 | A732V | WT | WT | C103Y |
| KNGF-HʹEʹIʹ24ʹ | Y38 | A732V | I286F | V154M | C103Y |
| J4HΔ38b | Δ38 | A732V | I286F | V154M | C103Y |
All viruses contain gB:NT (D285N/A549T).
Viruses contain either gD:ppNGF(Y38), which is able to enter cells via nectin-1, or gD:ppNGF(Δ38), which does not enter cells via nectin-1.
J4HΔ38 is a derivative of J4H.