Table 1.

Expression pattern of FcγR in different immune cells, its function, and its participation in the ADE of different viruses.

	FcγRI	FcγRIIa	FcγRIIb	FcγRIIc	FcγRllla	FcRIIIb
	(CD64)	(CD32a)	(CD32b)	(CD32c)	(CD16a)	(CD16b)
Expressed by human immune cells	Macrophages, Eosinophils, Neutrophils, and Dendritic cells.	Platelets, Macrophages, Neutrophils, and Eosinophils.	Platelets, Dendritic cells, B cells, Mast cells, Neutrophils, and Eosinophils.	Natural Killer cells depend on allele status.	Natural Killer cells, Macrophages, Neutrophils, and Eosinophils.	Macrophages, Neutrophils, and Follicular dendritic cells.
Binding specificity	IgG1, IgG3, and IgG4.	IgG.	IgG.	IgG.	IgG1 and IgG3.	IgG1 and IgG3.
Functions	Phagocytosis, respiratory burst activation, and cell activation.	Degranulation, Phagocytosis, and ROI production.	Inhibits the phagocytosis and release of the pro-inflammatory cytokines, Degranulation, platelet activation, and B cell activation.	Phagocytosis and clearing of immune complexes.	Antibody-dependent cell-mediated cytotoxicity (ADCC) initiation, and cytokine release.	Phagocytosis, cytokine, and chemokine release.
ADE participation of viruses	DENV, Ebola virus, PRRSV, and JEV.	DENV, FIPV, MERS-CoV, SARS-CoV, and WNV SARS-CoV-2.	SARS-CoV-2, DENV, WNV, and PRRSV.	Unknown.	DENV, Ebola virus, HIV, PRRSV, and JEV.	Unknown.