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. 2023 Jun 23;13(7):786. doi: 10.3390/metabo13070786

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Immunohistochemically stained COX2 renal cortex sections of rats. X400. (a) Renal cortex of control rats showed negative COX2 immuno-expression in the cytoplasm of proximal (PCT) and distal (DCT) convoluted tubules. (b) Rats treated with K₂Cr₂O₇ revealed strong positive COX2 immunoreaction in the cytoplasm of the proximal (PCT) and distal (DCT) convoluted tubules. (c) Rats pretreated with 200 mg/kg LME 200 displayed a moderate COX-2 immuno-expression in the cytoplasm of the proximal (PCT) and distal (DCT) convoluted tubules. (d) Rats pretreated with 400 mg/kg LME exhibited a mild level of COX-2 immuno-expression in the cytoplasm of the proximal (PCT) and distal (DCT) convoluted tubules. e) Rats pretreated with 200 mg/kg LMNS showed a mild level of COX-2 immunoreactivity in the cytoplasm of the proximal (PCT) and distal (DCT) convoluted tubules. (f) Rats pretreated with 400 mg/kg LMNS 400 revealed a negligible level of COX2 immunoreaction in the cytoplasm of the proximal (PCT) and distal (DCT) convoluted tubules.