Table 2.
Effects of oxadiazole derivatives Ox-6a-f on carrageenan-induced paw edema in rats.
| Group | 1st h | 3rd h | 6th h | 12th h |
|---|---|---|---|---|
| Saline Control | -- | -- | -- | -- |
| Carrageenan Control | -- | -- | -- | -- |
| Ibuprofen | 36.87 ± 4.21 | 54.03 ± 2.79 | 72.58 ± 1.82 | 84.71 ± 2.78 a |
| Ox-6a | 13.96 ± 8.61 | 36.82 ± 8.47 | 56.14 ± 4.72 | 74.52 ± 3.97 d |
| Ox-6b | 10.05 ± 2.56 | 21.51 ± 4.92 | 52.55 ± 1.82 | 57.96 ± 4.17 e |
| Ox-6c | 16.75 ± 8.22 | 23.38 ± 5.03 | 38.18 ± 4.94 | 51.59 ± 1.91 f |
| Ox-6d | 8.93 ± 3.48 | 30.11 ± 3.35 | 65.41 ± 2.04 | 76.64 ± 3.21 c |
| Ox-6e | 7.26 ± 3.48 | 26.07 ± 2.83 | 40.45 ± 2.04 | 52.44 ± 4.51 f |
| Ox-6f | 9.49 ± 1.67 | 29.31 ± 1.86 | 57.65 ± 1.73 | 79.83 ± 4.04 b |
Data values shown represent mean ± SD (n = 3). Means with different superscript (a–f) letters in the column are significantly (p < 0.05) different from one another.