Table 2.
Variants of exome-wide association study for 25-hydroxyVitamin D levels.
| SNP | Gene | HGVS ID | CHR | Position | A1 | A2 | Beta | SE (Beta) | p-Value |
|---|---|---|---|---|---|---|---|---|---|
| rs141064014 | MGAM | NC_000007.13:g.141736273G>A | 7 | 141736273 | G | A | −2.38 | 0.52 | 4.4 × 10−6 |
| rs7036592 | PHF2 | NC_000009.11:g.96425777C>T | 9 | 96425777 | C | T | −0.54 | 0.12 | 8.4 × 10−6 |
Statistical summary of the Lebanese ExWAS analysis using linear mixed models’ correction of principal population components, sex, and age with a p-value < 1 × 10−5. We used GRCh37/hg19 genome reference. Columns are SNP, single-nucleotide polymorphism rs ID; Gene, mapped genes affected by a variant from ANNOVAR; HGVS ID, Human Genome Variation Society sequence variant nomenclature descriptions from Ensembl; CHR, chromosome; A1, reference allele; BP, base pair; A2, alternative allele; Beta, variant effect size determined based on the allele A1; SE, the standard error for Beta; MAF, minor allele frequency determined based on the allele A1; p-value, p-value of ExWAS analysis. Abbreviations: MGAM, Maltase-glucoamylase; PHF2, PHD finger 2.