Table 1.
Inhibitory activity of reduced size peptide P23
| Peptide | Sequence | IC50 (mean ± SD) μM | CC50 (mean ± SD) μM |
|---|---|---|---|
| Vero E6 cell substrate | |||
| P23 | 884SGWTFGAGAALQIPFAMQMAYRF906 | 2.80 ± 2.68 | > 100 |
| PN21 | 886WTFGAGAALQIPFAMQMAYRF906 | 0.71 ±2.11 | > 100 |
| PN19 | 888FGAGAALQIPFAMQMAYRF906 | 0.20 ±1.11 | > 100 |
| PN17 | 890AGAALQIPFAMQMAYRF906 | 2.79 ±1.96 | > 100 |
| PC21 | 884SGWTFGAGAALQIPFAMQMAY904 | 8.33 ±3.60 | >100 |
| PC19 | 884SGWTFGAGAALQIPFAMQM902 | 9.43 ±2.44 | > 100 |
| PC17 | 884SGWTFGAGAALQIPFAM900 | 97.94 ±21.84 | > 100 |
| PNC19 | 886WTFGAGAALQIPFAMQMAY904 | 46.83 ±9.97 | > 100 |
| PNC15 | 888FGAGAALQIPFAMQM902 | >100 | > 100 |
| PN13 | 894LQIPFAMQMAYRF906 | 1.70 ±0.52 | > 100 |
| PN9 | 898FAMQMAYRF906 | 5.93 ±9.74 | > 100 |
| Vero E6/TMPRSS2 | |||
| PN19 | 888FGAGAALQIPFAMQMAYRF906 | 1.10 ± 0.11 | > 100 |
aValues obtained in two to three independent assays.