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hTopo I relaxation assay. Plasmid pHOT1, used as substrate, was incubated with hTopo I with or without the studied compounds 7b–7e (10 µM concentration), panel (A), and with or without ellipticine (10 and 50 µM concentration), panel (B). Lane A, relaxed DNA marker; lane B, pHOT1 supercoiled DNA, lane C, CTRL (DMSO), lane D–G, compounds 7b–7e 10 µM, respectively. Lane 1, pHOT1 supercoiled DNA; lane 2, CTRL (DMSO), lanes 3–4, ellipticine 10 and 50 µM, respectively.
