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. 2023 Jun 29;16(7):946. doi: 10.3390/ph16070946

Figure 4.

Figure 4

hTopo II decatenation assay. The catenated circles of kDNA, used as substrate, incubated with hTopo II with or without the studied compounds 7b–7e used at the concentrations of 10 µM (a) and 50 µM (b). Lane A, linear kDNA marker; lane B, decatenated kDNA marker; lane C, catenated circles of kDNA; lane D, CTRL (DMSO), lanes E–H, compounds 7b–7e, respectively. The same experiment was performed using ellipticine (c). Lane 1, decatenated kDNA marker; lane 2, linear kDNA marker; lane 3, CTRL (DMSO), lanes 4–5, ellipticine 10 and 50 µM, respectively.