Scheme 2.
Synthesis of 2-chloro- and 2-iodoacetamides 5a-f and 6a-f respectively. Reagents and conditions: (i) 1. ClCH2COCl, anhydrous benzene, boiling water bath, overnight, 2. NaHCO3 solution, (ii) KI, acetone, reflux, 4 h.
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