Table 2.
Characteristics and comparison between the 538 positive and negative healthcare workers (HCWs) to the anti-N (nucleocapsid) protein after the third dose of a COVID-19 vaccination, considering age, gender, anti-RBD IgG, anti-S1 IgG, and anti-S2 IgG.
| Parameters | COVID-19 V Anti-N IgG < 10 U/mL |
COVID-19 H Anti-N IgG ≥ 10 U/mL |
COVID-19 H vs. COVID-19 V p-Value (Test) |
|---|---|---|---|
| Healthcare workers (HCWs) | 65.4% (352) | 34.6% (186) | |
| Age | 45.2 ± 12.2 | 40.9 ± 12.1 | |
| 48 [38, 55] | 43 [30, 51] | 0.0001 * (MW) | |
| Gender %Male %Female |
52% (183) 48% (169) |
44.6% (83) 55.4% (103) |
0.10 (C) |
| anti-RBD IgG (U/mL) | (1N, 351P) | (1N, 185P) | p = 1.0 (F) |
| <10 | 7.0 ± 0.0 (n = 1) | 3.0 ± 0.0(n = 1) | - |
| [10, 100] | 49.8 ± 34.2 (n = 6) | - | - |
| >100 | 1600 [1600, 1600] (n = 345) | 1600 [1600, 1600] (n = 185) | p < 0.0001 * (MW) |
| anti-S1 IgG (U/mL) | (0 N, 352 P) | (1N, 185 P) | p = 0.35 (F) |
| <10 | - | 5.0 ± 0.0(n = 1) | - |
| [10, 100] | - | - | - |
| >100 | 1600 [872.5, 1600] (n = 352) | 1600 [1600, 1600] (n = 185) | p < 0.0001 * (MW) |
| anti-S2 IgG (U/mL) | (63 N, 289 P) | (9 N, 176 P) | <0.0001 * (C) |
| <10 | 4 [3, 7] (n = 63) | 6 [4.75, 8.25] (n = 9) | p = 0.19 (MW) |
| [10, 100] | 28 [17, 47.75] (n = 243) | 47 [27.25, 64] (n = 135) | p < 0.0001 * (MW) |
| >100 | 114 [82, 213] (n = 46) | 133 [77.75, 180.5] (n = 41) | p = 0.93 (MW) |
* = significant test, N = negative, P = positive, C = chi-square test, F = Fisher’s exact test, MW = Mann–Whitney test.