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The impact of everolimus treatment on cell functioning.
| Down-Regulation | Up-Regulation | Cellular Effects |
|---|---|---|
| 4E-BP1 and S6K1 | LC3B and beclin1 | |
| CDK2 | FOXO family | |
| PPARγ | Increases response to radiation therapy | |
| HIF-Iα | ||
| PPARα | Increases response to radiation therapy | |
| PGC1α | ||
| Akt | BAD | |
| Myc | ||
| Cyclin A and D1 | GSK3 | G0/G1 cell cycle arrest |
| Myc | CDK inhibitors p21 cip1 and p27 kip1 | Decreased cellular proliferation |
| VEGF |
