Figure 21.

A 3D graph of the predicted and calculated anti-hypercholesterolemic activity of the steroid phosphate esters 104, 105, 106. With a confidence level of over 96%, the graph reflects a high degree of certainty in the accuracy of the predicted and calculated activity values. It is noteworthy that various plants, such as Hemidesmus indicus, Pulicaria gnaphalodes, Pandanus tectorius fruits, Buchholzia coriacea, and Swietenia mahagoni, have been recognized for their anti-hypercholesterolemic properties, as demonstrated by their extracts [138,139,140,141,142]. Additionally, extracts from brown algae and the cyanobacterium Arthrospira platensis have also shown an anti-hypercholesterolemic effect. Interestingly, steroid phosphate esters derived from invertebrates exhibit strong anti-hypercholesterolemic properties. This highlights the potential of these compounds as promising candidates for the development of therapeutic interventions aimed at managing high cholesterol levels.