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. 2023 Jun 27;15(7):1454. doi: 10.3390/v15071454

Table 1.

Parameters of the 4 alternative models fit to Datasets 1–4 (excluding data with CTL=108cell/mL) and metrics of relative quality of the model fits. Estimated parameters: α is a dimensionless inverse of the effective fraction; r is given in units of per day; h is in cell/mL; g1 is in per day; g2 is in cell/mL. The parameter k had different units in different models: per OT1 cell/mL per day, per day, per OT1 (cell/mL)n per day, and per OT1 cell/mL per day for MA (Equation (3)), Sat (Equation (4)), Power (Equation (5)), and SiGMA (Equation (6)), respectively; n is a dimensionless parameter. The parameter estimates and 95% confidence intervals for the best-fit SiGMA model were: α=2.71(2.5–2.9), g0=0.12(0.036–0.2)/day, g1=0.64(0.55–0.73)/day, g2=6.72(4.14–17.57) ×103cell/mL, and k=3.3(3.15–3.4)×107cell/mL/day; the model fits are shown in Figure 2. The best-fit model (with the highest w) is highlighted in blue.

Datasets 1–4 (E107 cell/mL): n = 431
Model α r, 1/day k h n g0 g1 g2 SSR AIC Δ w
MA 2.77 0.576 3.79×107 164 814 160 0
Sat 2.81 0.744 6 5.34×106 118.5 677 23 0
Power 2.79 0.744 2.23×104 0.606 116 668 14 0
SiGMA 2.71 3.29×107 0.12 0.64 6715 112 654 0 1