Table 1.
LogD7.4 and stability in PBS and mouse serum of 203Pb-labeled DOTAM-TATE, eSOMA-01, eSOMA-02, and eSOMA-03.
Compound | LogD7.4 b | Stability in PBS(%) a | Stability in PBS(%) a |
---|---|---|---|
1 h 4 h 24 h | 1 h 4 h 24 h | ||
[203Pb]Pb-DOTAM-TATE | −1.41 ± 0.01 | 99 99 99 | 99 99 99 |
[203Pb]Pb-eSOMA-01 | −1.99 ± 0.03 | 100 100 100 | 100 100 100 |
[203Pb]Pb-eSOMA-02 | −1.88 ± 0.03 | 97 97 97 | 97 97 97 |
[203Pb]Pb-eSOMA-03 | −1.36 ± 0.06 | 70 40 15 | 85 70 60 |
a Results are expressed as a percentage of intact labeled ligand after incubation at 37 °C (n = 1); b n = 3.