Table 4.
Absorbed dose per administered activity (Gy/MBq; with RBE = 5) in H69-tumor xenograft and organs for [212Pb]Pb-DOTAM-TATE, [212Pb]Pb-eSOMA-01, and [212Pb]Pb-eSOMA-02.
| Tissue | [212Pb]Pb-DOTAM-TATE | [212Pb]Pb-eSOMA-01 | [212Pb]Pb-eSOMA-02 |
|---|---|---|---|
| Tumor | 26.61 ± 19.27 | 35.49 ± 9.89 | 14.73 ± 5.73 |
| Lungs | 2.06 ± 0.29 | 3.20 ± 0.40 | 2.55 ± 0.28 |
| Liver | 6.93 ± 0.64 | 9.03 ± 2.24 | 8.46 ± 1.96 |
| Spleen | 0.56 ± 0.14 | 0.73 ± 0.19 | 1.17 ± 0.49 |
| Stomach wall | 4.42 ± 1.30 | 5.78 ± 0.77 | 2.92 ± 0.33 |
| Large Intestine | 1.64 ± 0.30 | 2.03 ± 0.26 | 1.74 ± 0.39 |
| Pancreas | 3.65 ± 0.28 | 5.40 ± 0.14 | 4.36 ± 0.28 |
| Kidneys | 140.03 ± 17.95 | 121.73 ± 14.57 | 147.44 ± 36.20 |
| K/T | 5.26 ± 3.90 | 3.43 ± 1.10 | 10.01 ± 4.60 |