Table 1.

Overview of collected AKT-targeted in silico studies according to the ligand binding site and the main computational methodology.

Site	Computational Methodology	Refs
ATP-binding site	docking-based	[20,22,23,24,25,26,27]
	pharmacophore-based	[28,29,30,31]
	ML	[32]
	QSAR	[33]
Allosteric site	docking-based	[34,35]
	pharmacophore-based	[36]
PI3P-binding site	pharmacophore-based	[37,38]