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. 2023 Jul 18;15(7):1972. doi: 10.3390/pharmaceutics15071972

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The main composition of LNPs for nucleic acid delivery. The LNPs showed mRNA encapsulated into the core of the nanocarrier. ALC-0315, [(4-Hydroxybutyl)azanediyl]di(hexane-6,1-diyl) bis(2-hexyldecanoate); SM-102, 8-[(2-hydroxyethyl)[6-oxo-6-(undecyloxy)hexyl]amino]-octanoic acid, 1-octylnonyl ester; DSPC, 1,2-distearoyl-sn-glycero-3phosphocholine; DOPE, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine; ALC-0159, Methoxypolyethyleneglycoloxy(2000)-N,N-ditetradecylacetamide; PEG-DMG, 1,2-Dimyristoyl-rac-glycero-3-methoxypolyethylene glycol.