Figure 4.

Effect of CHIKV-EIG treatment on body weight changes of IFNαβR^−/− mice lethally challenged with CHIKV strain 99,659. Groups of mice were administered CHIKV-EIG via i.p. at 100 mg/kg daily for five consecutive days beginning 5 h or one day after infection with 10³ PFU of CHIKV strain 99,659 via i.d. Control animals were administered PBS via i.p. for five consecutive days beginning one day post-infection. Data points represent the average (±one standard error of the mean) percentage of baseline body weight for each day for each study group.