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. 2023 Jun 29;15(7):1479. doi: 10.3390/v15071479

Figure 7.

Figure 7

Reduction in (A) MCP1 and (B) RANTES expression by treatment with CHIKV-EIG in infected hindlimb tissue of DBA/1J mice at 6 dpi. The cytokines (A) MCP1 and (B) RANTES were quantified in infected hindlimb tissue at 6 dpi (n = 7 per group). Groups of mice administered various dose levels of CHIKV-EIG via i.p. route (100, 50, 25 mg/kg) daily for five days or (100 mg/kg) for three days. All CHIKV-EIG treatments were initiated 4 h prior to infection with 105.5 CCID50 CHIKV strain LR-OPY1. Control animals were administered via i.p. for five days beginning 4 h prior to infection, or administered methotrexate s.c. at 2 mg/kg/day for five days beginning one day prior to infection. Symbols represent individual animals. Horizontal lines represent group median values and interquartile ranges. *: p < 0.05 compared to vehicle control; **: p < 0.01 compared to vehicle control.