Table 3.
Effect of CHIKV-EIG treatment on time to peak percent body weight loss in IFNαβR−/− mice compared to vehicle controls.
| Treatment Group | Mean Peak Percent Weight Loss (95% CI) |
Median Time to Peak Weight Loss in Days (95% CI) |
Sidak-Adjusted Log-Rank Test vs. Vehicle Control |
|---|---|---|---|
| Vehicle Control | 8.17 (5.56, 10.78) | 5.00 (3.00, 5.00) | n/a |
| CHIKV-EIG 100 mg/kg/day (qd X5, i.p. beginning 5 h post-infection) |
7.70 (3.19, 12.20) | 8.00 (7.00, 9.00) | 0.0057 * |
| CHIKV-EIG 100 mg/kg/day (qd X5, i.p. beginning day 1 post-infection) |
9.53 (5.71, 13.34) | 11.0 (4.00, 11.0) | <0.001 * |
* Denotes significant p value (≤0.05). p values are not adjusted for multiple comparisons.