Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Effect of inhibitor 1c on MTase activity of full-length SARS-CoV-2 nsp14. (a) Increasing concentrations of nsp14 were incubated with GpppA for 60 min in the presence of [3H]-SAM in a radioactive biochemical assay. (b) Nsp14 MTase activity monitored in the absence or presence of inhibitor 1c using [3H]-SAM. m7GpppA served as a methylated control substrate, performed in the absence of 1c. Experiments were performed in triplicate. Error bars show standard deviations.
