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Effect of ipconazole (20 and 50 µM) after a 24 h incubation period on gene expressions of inflammation mediators NFκB (A), TNFα (B), and IL6 (C) in SH-SY5Y cells. Data represent the mean ± SEM of three repetitions. Up-regulated (red bar) genes are significant (* p < 0.05, ** p < 0.01, and *** p < 0.001) compared with the vehicle (black bar). The central figure shows the possible mechanism of ipconazole-induced inflammation (adapted from [20]).
