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Effect of ipconazole (20 and 50 µM) after a 24 h incubation period on gene expressions of antioxidant mediators NRF2 (A), SOD (B), and GPx (C) in SH-SY5Y cells. Data represent the mean ± SEM of three repetitions. Down-regulated (green bar) genes are significant (* p < 0.05 and ** p < 0.01) compared with the vehicle (black bar). The central figure shows the possible mechanism of antioxidant mediators decreased by ipconazole (adapted from [21]).
