Table 3.
Top Ten Molecular Functions in H5N1 Infection. Colour map indicates; Red colour: Low value, Yellow colour: Medium value, Green colour: High value.
| Gene Ontology Terms | Genes | Count | p-Value | Fold Enrichment | FDR |
|---|---|---|---|---|---|
| Identical protein binding | CRP, JUN, SFTPD, FN1, SOD1, PYCARD, IKBKB, CEACAM1, IRF3, NCL, TNFSF10, MAP3K7, RIGI | 13 | 8.73 × 10−5 | 3.66958382 | 0.012314 |
| Protein binding | IFITM3, CRP, NDUFA13, CXCL8, IFNA1, IKBKB, PYCARD, NXF1, NRAS, MAPK8, SUMO1, CASP10, UBD, TNFSF10, MARCHF8, MAP3K7, JUN, FYB1, CHUK, IFNB1, SFTPD, FN1, SCRIB, MAPK14, RUNX1, SOD1, CXCL10, ITCH, IL6, CEACAM1, IRF3, CD209, NCL, NUP98, RIGI, NFE2L2 | 36 | 2.37 × 10−4 | 1.387409468 | 0.01641 |
| CXCR chemokine receptor binding | CXCL10, ITCH, CXCL8 | 3 | 4.08 × 10−4 | 96.76410256 | 0.01641 |
| MAP kinase activity | MAPK8, MAPK14, MAP3K7 | 3 | 4.66 × 10−4 | 90.71634615 | 0.01641 |
| Enzyme binding | PYCARD, JUN, MAPK8, SUMO1, FN1, MAPK14 | 6 | 0.001053 | 7.443392505 | 0.024908 |
| Ubiquitin-like protein ligase binding | ITCH, JUN, SUMO1 | 3 | 0.00106 | 60.4775641 | 0.024908 |
| IkappaB kinase activity | IKBKB, CHUK | 2 | 0.00603 | 322.5470085 | 0.118703 |
| Cytokine activity | IL6, IFNA1, IFNB1, TNFSF10 | 4 | 0.006735 | 10.07959402 | 0.118703 |
| Protein serine/threonine kinase activity | IKBKB, MAPK8, CHUK, MAPK14, MAP3K7 | 5 | 0.007755 | 6.17118001 | 0.119996 |
| Scaffold protein binding | IKBKB, CHUK, MAP3K7 | 3 | 0.00851 | 21.03567447 | 0.119996 |
| Colour map | Low | Medium | High | ||