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. 2023 Jun 28;13(7):801. doi: 10.3390/metabo13070801

Figure 5.

Figure 5

Responder vs. Non-responder Predictive Analyses of GSIS based on Metabolite Profiles. (A) Differentiation of urine sample extracts (5% dose only) by highest vs. lowest quartiles for GSIS parameters. GSIS was compared between the highest (black bars) vs. lowest quartiles (gray bars) by t-tests, with the Holm-Sidak method to control for multiple comparisons (1 family, 4 t-tests: 1 per GSIS response measure), with the overall family α = 0.05. Each GSIS measure was analyzed individually, without assuming a consistent SD. Comparison of urine compositions between the most effective vs. least effective samples for each GSIS measure including insulin secretion during low glucose (B), during high glucose (C), insulin secretion fold induction (D), and insulin content (E). Within each GSIS measure, levels of each compound class were compared between the highest vs. lowest quartiles by t-tests, with the Holm-Sidak method to control for multiple comparisons (1 family per GSIS measure, 6 t-tests: 1 per compound class). For all tests: **** p < 0.0001.