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. 2023 Jun 28;13(7):801. doi: 10.3390/metabo13070801

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Predictive Value of Metabolite Profiles on GSIS activity. Comparison of GSIS response between urine derived samples with the highest and lowest quartiles of concentrations of various classes of compounds, including total (A) native flavanols, (B) microbial metabolites, (C) valerolactones, (D) phenylalkyl acids, (E) cinnamic acids and (F) hippuric acids. Values are presented as mean ± SEM. Within each compound class, response was compared between the highest vs. lowest quartiles by t-tests, with the Holm-Sidak method to control for multiple comparisons (1 family per compound class, 4 t-tests: 1 per response measure). * p < 0.05.