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. 2023 Jun 29;59(7):1225. doi: 10.3390/medicina59071225

Figure 3.

Figure 3

(A–D) Morphology of cultured fibroblasts (original magnification ×4, scale of 500 μm): early passages (~3rd–4th) of a fibroblast culture of the proband (A) and control individual before the gene-editing experiment (B); late passages (~10th–15th) of a fibroblast culture of the proband (C) and control individual after the gene-editing experiment (D). (E,F) Senescence of cultured fibroblasts (original magnification ×40, scale of 100 μm): early passages (~3rd–4th) of the fibroblast culture of the proband (E) and control individual before the gene-editing experiment (F).