Table 1.
First author, number of patients, type of infection, aetiologic data, outcome, and dalbavancin schedule of administration of every included study analysed.
| First Author | Ref. | N. of Patients | Type of the Study | Type of Infection (n) | Aetiology (n) | Outcome (n) | DBV Dosage (n) | N. Administrations (n) |
|---|---|---|---|---|---|---|---|---|
| Rappo U, et al. | [15] | 70 | Randomized controlled trial | Osteomyelitis (70) |
S. aureus (42) CoNS (14) Enterococcus spp. (8) Streptococcus spp. (3) Other Gram-positive (13) Gram-negative and fungi (3) |
Clinical cure (63) Clinical cure after different therapy (1) Lost to FU (2) Unrelated death (1) NA (3) |
1500 mg (70) | 1 dose (3) 2 doses, 1 week apart (67) |
| Morata L, et al. | [16] | 19 | Retrospective | Osteomyelitis (12) Arthritis or spondylodiscitis (7) |
S. aureus (10) CoNS (4) Enterococcus spp. (2) Streptococcus spp. (3) Other Gram+ (2) |
Clinical cure (17) Clinical failure (1) Relapse (1) |
NA | NA |
| Almangour TA, et al. | [20] | 27 | Retrospective | Osteomyelitis (16) Spondylodiscitis (14) |
S. aureus (27) CoNS (1) Streptococcus spp. (2) Gram-negative and fungi (1) |
Clinical cure (24) Clinical failure (1) NA (2) |
1500 mg (11) 1000 + 500 mg (15) 2000 + 500 mg (1) |
1 dose (6) 2 doses, 1 week apart (6) 3 doses > 1 week apart (1) 3 doses, 1 week apart (2) 4 doses,1 week apart (4) 4 doses > 1 week apart (19) >4 doses (7) |
| Stroffolini G, et al. | [21] | 25 | Prospective | Osteomyelitis (9) Spondylodiscitis (6) Arthritis (3) |
NA | Clinical cure (9) NA (16) |
1500 mg (25) | 1 dose (3) 2 doses, 1 week apart (9) NA (13) |
| Ramadan MS, et al. | [22] | 13 | Retrospective | Spondylodiscitis (13) |
S. aureus (6) CoNS (4) Other Gram-positive (1) Gram-negative and fungi (2) |
Clinical cure (8) Relapse (5) |
1500 mg (12) 1000 + 500 mgfor 5 times (1) |
2 doses, 1 week apart (12) >4 doses (1) |
| Brescini L, et al. | [23] | 13 | Retrospective | Osteomyelitis (8) Arthritis (5) |
NA | NA (13) | NA | NA |
| De Nicolò A, et al. | [24] | 10 | Prospective | Osteomyelitis (4) Spondylodiscitis (3) Arthritis (3) |
S. aureus (7) CoNS (2) Streptococcus spp. (1) |
NA (10) | 1500 mg (10) | 1 dose (3) 2 doses, 1 week apart (7) |
| Navarro-Jiménez G, et al. | [25] | 23 | Retrospective | Osteomyelitis (23) |
S. aureus (12) Other Gram-positive (7) CoNS (3) Enterococcus spp. (1) |
Clinical cure (20) Clinical failure (3) |
1000 + 500 mg for 5 times (8) 1000 + 500 + 500 + 500 mg (1) 1000 + 500 mg for 9 times (1) 1500 mg (9) 1000 mg (1) 750 mg (1) 1500 + 500 mg (2) |
1 dose (5) 2 doses, 1 week apart (5) 3 doses, 1 week apart (2) 4 doses, 1 week apart (1) >4 doses (10) |
| Tobudic S, et al. | [26] | 38 | Retrospective | Osteomyelitis (20) Spondylodiscitis (14) Septic arthritis (4) |
NA | Clinical cure (19) Clinical failure (7) Clinical cure after different therapy (8) NA (4) |
1000 + 500 (6) 1500 + 1000 mg (28) 1500 + 1500 mg (4) |
NA |
| Cain AR, et al. | [18] | 42 | Retrospective | Osteomyelitis (42) |
S. aureus (23) NA (19) |
Clinical cure (20) Relapse (13) Clinical failure (9) |
1500 mg (42) | 2 doses, 1 week apart (42) |
| Cojutti PG, et al. | [27] | 27 | Retrospective | Osteomyelitis (16) Spondylodiscitis (9) Arthritis (2) |
NA | NA (27) | 1000 mg (NA) 1500 mg (NA) |
NA |
| Cojutti PG, et al. | [11] | 2 | Prospective | Spondylodiscitis (1) Arthritis (1) |
S. aureus (1) NA (1) |
Clinical cure (1) Relapse (1) |
1500 mg (2) | 2 doses, 1 week apart (2) |
| Lueking R, et al. | [28] | 19 | Retrospective | Osteomyelitis (15) Arthritis (4) |
MSSA (1) NA (18) |
Clinical cure (18) Relapse (1) |
1500 + 1500 (1) NA (18) |
2 doses, 1 week apart (1) NA (14) |
| Tuan JJ, et al. | [29] | 23 | Retrospective | Osteomyelitis (21) Arthritis (2) |
NA | Clinical cure (21) Clinical failure (1) Death from BJIs (1) |
NA | NA |
| Mazzitelli M, et al. | [30] | 14 | Retrospective | Spondylodiscitis (14) | S. aureus (14) | Clinical cure (14) | 1500 mg (14) | 3 doses >1 week apart (7) 4 doses > 1 week apart (5) |
| Almangour TA, et al. | [31] | 9 | Retrospective | Osteomyelitis (6) Spondylodiscitis (3) |
S. aureus (9) | Clinical cure (9) | NA (9) | NA |
| Dinh A, et al. | [17] | 48 | Retrospective | NA | NA | Clinical cure (35) Clinical failure (11) NA (2) |
1000 mg (2) 1500 mg (37) 1500 + 1000 mg (1) 1500 + 500 mg (2) 1000 + 500 + 500 + 500 mg (6) |
1 dose (5) 2 doses > 1 week apart (4) 2 doses, 1 week apart (30) 3 doses, 1 week apart (1) 4 doses > 1 week apart (3) >4 doses (5) |
| Loupa CV, et al. | [32] | 1 | Case report | Osteomyelitis (1) | Enterococcus spp. (1) | Lost at FU (1) | 1500 mg (1) | 2 doses > 1 week apart (1) |
| Bork JT, et al. | [33] | 14 | Retrospective | Osteomyelitis (13) Arthritis (1) | NA | Clinical cure (6) Clinical failure (4) Lost to FU (3) Unrelated death (1) |
NA | NA |
| Ritchie H, et al. | [34] | 1 | Case report | Spondylodiscitis (1) | S. aureus (1) | Clinical cure after different therapy (1) | 1500 mg (1) | 1 dose (1) |
| Almangour TA, et al. | [35] | 1 | Case report | Spondylodiscitis (1) | S. aureus (1) | Clinical cure (1) | 1000 + 1000 + 500 mg for 6 times (1) | >4 doses (1) |
| Molina Collada J, et al. | [36] | 1 | Case report | Septic arthritis (1) | Other Gram-positive (1) | Clinical cure (1) | 1500 mg (1) | 1 dose (1) |
| Bryson-Cagn C, et al. | [37] | 10 | Retrospective | Osteomyelitis (4) Septic arthritis (3) Spondylodiscitis (3) |
S. aureus (10) | Clinical cure (6) Clinical failure (3) NA (1) |
1000 mg (5) 1500 + 1000 + 500 + 500 + 500 mg (1) 1000 + 500 mg (3) 1000 + 500 + 500 mg (1) |
1 dose (5) 2 doses, 1 week apart (3) 3 doses, 1 week apart (1) >4 doses (1) |