TABLE 3.

Summary of the effects of Th1 and Th2 cytokine coinjection on IgG levels, the ratio of IgG2a to IgG1, Th-cell proliferation responses, mortality, and morbidity^a 

Cytokine	IgG level	IgG2a/IgG1	Th-cell response	Mortality	Morbidity
Th1 types
IL-2	↑	—	↑	↓	↓
IL-12	↓	↑	↑	↓	↓
IL-15	↑	↑	↑	↓	↓
IL-18	—	—	↑	↓	↓
Th2 types
IL-4	—	↓	↑	↑	ND
IL-10	—	—	↓	↑	ND

^a↑ and ↓, increase and decrease of the responses, respectively, compared to that without cytokine coinjections; —, no change; ND, not determined.