Table 2.

Quality assessment of the included studies using SYRCLE’s risk of bias tool for animal studies.

Study	Selection Bias			Performance Bias		Detection Bias		Attrition Bias	Reporting Bias	Other
	Was the Allocation Sequence Adequately Generated and Applied?	Were the Groups Similar at Baseline or Were They Adjusted for Confounders in the Analysis?	Was the Allocation Adequately Concealed?	Were the Animals Randomly Housed during the Experiment?	Were the Caregivers and/or Investigators Blinded from Knowledge of Which Intervention Each Animal Received during the Experiment?	Were Animals Selected at Random for Outcome Assessment?	Was the Outcome Assessor Blinded?	Were Incomplete Outcome Data Adequately Addressed?	Are Reports of the Study Free of Selective Outcome Reporting?	Was the Study Apparently Free of Other Problems that could Result in High Risk of Bias?
Makino et al. [31]	Unclear	Yes	Unclear	Unclear	No	No	Unclear	Yes	Yes	Yes
Makino et al. [32]	Unclear	Yes	Unclear	Unclear	No	No	Unclear	Yes	Yes	Yes
Makino et al. [33]	Unclear	Yes	Unclear	Unclear	No	No	Unclear	Yes	Yes	Yes
Makino et al. [34]	Unclear	Yes	Unclear	Unclear	No	No	Unclear	Yes	Yes	Yes
Sakurai et al. [35]	Yes	Yes	Unclear	Unclear	Unclear	No	Unclear	Yes	Yes	Yes