Table 2.

Calculated logP (clogP), clogD, tPSA and measured HPLC logD values.

Substance	clogP	clogD	tPSA (Å2)	${\mathbf{\mu }\mathbf{HPLC} \mathbf{log}\mathit{P}}_{\mathbf{OW}}^{\mathbf{pH} 7.4}$
1	4.60	2.73	68.23	3.16 ± 0.16
1a	6.93	6.01	57.23	4.90 ± 0.27
1b	7.18	6.21	57.23	5.02 ± 0.28
2	4.41	3.64	71.95	3.88 ± 0.12
2a	4.95	4.42	63.16	4.13 ± 0.16
2b	4.81	3.83	63.16	3.97 ± 0.13
2c	5.35	4.64	54.37	4.28 ± 0.18
2d	5.37	4.52	89.46	4.23 ± 0.17