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. Author manuscript; available in PMC: 2023 Jul 29.
Published in final edited form as: Med Eng Phys. 2022 Jun 30;106:103843. doi: 10.1016/j.medengphy.2022.103843

Fig. 1.

Fig. 1.

Computational modeling of aging and young extracellular matrix (ECM)-mimetic fibrous networks (aging and young networks for short, respectively). (a) Human skin tissue, composed of the epidermis and dermis. (b) Fiber orientation in aging and young networks. ECM fibers are highly aligned in the aging networks while randomly oriented in the young networks. (c) 1D Parallel and perpendicular fibrous networks, 2D Parallel and perpendicular fibrous networks of interwoven chains, and 3D cubic fibrous networks (1D/2D parallel, perpendicular, and 3D cubic networks for short, respectively) to mimic the aging networks, and 3D randomly oriented networks consisting of the number of 30 fibers (F30) and 50 fibers (F50) to mimic the young networks.