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Workflow of PBPK-model development (A) and prediction of different drugs and their validation with observed plasma concentration time profiles from Phase 1 ADME studies. (B) Applied models for the different APIs depending on available literature data (details can be found in Section 2.4.1, Section 2.4.2, Section 2.4.3, Section 2.4.4, Section 2.4.5 and Section 2.4.6).
