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Simulated plasma concentration time profile using GastroPlus® (blue line) and observed pharmacokinetic data (red dots): (A) aprepitant after a 2 h infusion, (B) celecoxib following an oral solution, (C) fenofibrate administered as oral solution, (D) nimodipine administered by a single injection, (E) itraconazole after infusion of a cyclodextrin-based formulation, (F) itraconazole after oral administration of a solution formulation, and (G) ritonavir administered as oral solution.
