Table 1.
Participant characteristics and association to incident Alzheimer’s disease and all-cause dementia diagnosis within 17 years
| Predictor |
Alzheimer’s disease n (%) |
All-cause dementia n (%) |
Participants without dementia diagnosis n (%) |
Alzheimer’s disease OR (95% CI) p-value |
All-cause dementia OR (95% CI) p -alue |
|---|---|---|---|---|---|
| n | 153 | 464 | 5301 | - | - |
| Age, mean ± SD | 66.6 ± 5.2 | 66.9 ± 5.2 | 61.3 ± 6.4 | 1.16 (1.12–1.24) < .0001 | 1.17 (1.15–1.19) < .0001 |
| Male | 67 (43.8) | 227 (48.9) | 2423 (45.7) | Ref | Ref |
| Female | 86 (56.2) | 237 (51.1) | 2878 (54.3) | 1.12 (0.81–1.55) .55 | 0.89 (0.73–1.09) .26 |
| APOE4 – | 76 (50) | 280 (60.7) | 3970 (75.4) | Ref | Ref |
| APOE4 + | 76 (50) | 181 (39.3) | 1299 (24.7) | 3.27 (2.35–4.55) < .0001 | 2.14 (1.74–2.63) < .0001 |
| Kunkle PRS | |||||
| Q1 | 27 (17.7) | 103 (22.2) | 1338 (25.2) | Ref | Ref |
| Q2 | 32(20.9) | 102 (22.0) | 1339 (25.3) | 1.10 (0.65–1.86) .71 | 0.92 (0.69–1.24) .59 |
| Q3 | 35 (22.9) | 103 (22.2) | 1339 (25.3) | 1.20 (0.72–2.00) .49 | 0.91 (0.68–1.21) .51 |
| Q4 | 59 (38.6) | 156 (33.6) | 1285 (24.2) | 2.19 (1.37–3.51) .001 | 1.49 (1.14–1.96) .004 |
| Bellenguez PRS | |||||
| Q1 | 24 (15.7) | 98 (21.1) | 1343 (25.3) | Ref | Ref |
| Q2 | 39 (25.5) | 105 (22.6) | 1336 (25.2) | 1.63 (0.97–2.75) .06 | 1.09 (0.81–1.46) .58 |
| Q3 | 40 (26.1) | 122 (26.3) | 1320 (24.9) | 1.68 (1.001–2.83) .048 | 1.23 (0.92–1.64) .15 |
| Q4 | 50 (32.7) | 139 (30.0) | 1302 (24.6) | 2.09 (1.27–3.44) .0039 | 1.38 (1.04–1.82) .03 |
|
Kunkle PRS per SD increase |
- | - | - | 1.51 (1.30–1.75) < .0001 | 1.30 (1.12–1.36) < .0001 |
|
Bellenguez PRS per SD increase |
- | - | - | 1.32 (1.11–1.56) .001 | 1.14 (1.03–1.26) .01 |
Note: Logistic regression analyses adjusted for age, sex, and 10 principal components. Bold values denote statistical significance at the p < .05 level
Abbreviations: APOE e4 + 1 or more e4 alleles, APOE e4—no e4 alleles, CI confidence interval, OR odds ratio, SD standard deviation, Q quartile